Baker Mayfield, NFL's worst offense meet top-ranked 49ers defense. San Francisco has been dominant defensively with Nick Bosa's NFL-best six sacks leading a fearsome pass rush and playmaking safety Talanoa Hufanga anchoring the back end. The Niners have given up only 37 points to opposing offenses — tied for the second fewest through four games since 2010 — and have allowed 3.81 yards per play, the lowest mark through four games since 2008.
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